Please answer these questions

4. What are the key lifestyle modifications recommended for heart failure management?

5. What are the Class I drugs recommended for heart failure with reduced ejection fraction (HFrEF) according to ESC 2021 guidelines?

6. What are the benefits of ACE inhibitors in the treatment of HFrEF?

7. What are the common side effects of ACE inhibitors?

8. Can you provide examples of ACE inhibitors?

1. What is neprilysin, and how does its inhibition contribute to the treatment of heart failure?

2. How do ARNIs (Valsartan-sacubitril) impact the renin-angiotensin-aldosterone system (RAAS)?

3. Why should valsartan-sacubitril not be administered concurrently or within 36 hours of an ACE inhibitor, and what is the associated risk?